Studies on Transfer of Injected Cefmenoxime to Exudates(blister)of Wounds of Burn Patients

The transport of cefmenoxime,a cephalosporin antibiotic,into three kinds of exudates (exudate from excoriated skin,exudate from burn wounds,and burn blister fluid)from blood was studied on 37 burn patients after they were given an intravenous bolus of 50mg cefmenoxime per kg body weight.Concentrations of cefmenoxime in serum and in the above exudates or fluid were determined by bioassay.Concentrations of cefmenoxime in serum reached 189+29.7pg/m1(meantSD)15min after administration,decreasing to 4.8+1.3pgiml at 8 hr.Peak concentrations of the antibiotic in exudates from burn wounds and excoriated skin and in blister fluid of burn patients were all found at 1 hr. Calculated by a two-compartment open model,the half-life of the elimination phase (ham)was 1.53hr;volume of distribution(Vdp),0. 331/kg;and area under the curve (AUC),346pg-hr/ml.Cmtz(maximum concentration),Tm,(time of maximum concentration),and apparent transport ratios(F:kydk217.)for exudates from excoriated skin,exudates from burn wounds,and burn blister fluid were 34.9,19.7,22.9pg/m1 1.39,1.47,2.03h;and 0.47,0.28,0.43,respectively.